Deep learning using neural networks relies on a class of machine-learnable models
constructed using 'differentiable programs'. These programs can combine mathematical …

Identifying genomic locations of transcription-factor binding sites, particularly in higher
eukaryotic genomes, has been an enormous challenge. Various experimental and …

Sequence preferences of DNA binding proteins are a primary mechanism by which cells
interpret the genome. Despite the central importance of these proteins in physiology …

Protein-binding microarray (PBM) technology provides a rapid, high-throughput means of
characterizing the in vitro DNA-binding specificities of transcription factors (TFs). Using high …

Abstract Man and Stormo and Bulyk et al. recently presented their results on the study of the
DNA binding affinity of proteins. In both of these studies the main conclusion is that the …

We employ a biophysical model that accounts for the non-linear relationship between
binding energy and the statistics of selected binding sites. The model includes the chemical …

To the Editor: In his News Feature published in the February issue, Michael Eisenstein
outlines several alternative methods of drug delivery1 and discusses how several targets in …

Although many of the physiological effects of corticosteroid stress hormones on neuronal
function are well recognised, the underlying genomic mechanisms are only starting to be …

Protein–DNA interactions play a central role in transcriptional regulation and other biological
processes. Investigating the mechanism of binding affinity and specificity in protein–DNA …

DNA-binding proteins (DNA-BPs) play a pivotal role in various intra-and extra-cellular
activities ranging from DNA replication to gene expression control. Attempts have been …