The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

Telomerase is required for the maintenance of telomere length and is an important
determinant for cell immortalization. In human cells, telomerase activity is due to the …

Toll-like receptor 8 (TLR 8) belongs to a subgroup of the TLR family that recognizes nucleic
acids and that is involved in the protection against viruses. In mammals, TLR7 and 8 have …

SV40 LT and ST antigens cooperate to induce the proliferation and eventual transformation
of several human cell types. In natural virus infections, ST often enhances the function of LT …

In vivo studies have previously shown that Saccharomyces cerevisiae ribosomal protein
(RP) gene expression is controlled by the transcription factor repressor activator protein 1 …

FOXM1c transactivates the c‐myc promoter via the P1 and P2 TATA boxes using a new
mechanism. Whereas the P1 TATA box TATAATGC requires its sequence context to be …

One set of genes sufficient for transformation of primary human cells uses the combination of
Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and …

Recruitment of a RNA polymerase II complex by the glutamine-rich Q2 domain of cAMP
response element-binding protein (CREB) allows basal transcriptional activity, while …

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor
necrosis factor (TNF) family of cytokines, acts on responsive cells via binding to a cell …

The colonic epithelium contains three major types of mature cells, namely, absorptive,
goblet, and enteroendocrine cells. These cells are maintained by a complex process of cell …