R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development
and disease through their regulation of transcription, RNA processing and translation …

Conflicts between transcription and replication are a potent source of DNA damage. Co-
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play
important biological roles and are implicated in pathology. Even so, proteins recognizing …

R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

Given that genomic DNA exerts its function by being transcribed, it is critical for the
maintenance of homeostasis that DNA damage, such as double-strand breaks (DSBs) …