Presynaptic active zones in invertebrates and vertebrates
F Ackermann, CL Waites, CC Garner - EMBO reports, 2015 - embopress.org
The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SV s) at
specialized regions of the presynaptic membrane called active zones (AZ s). These regions …
specialized regions of the presynaptic membrane called active zones (AZ s). These regions …
Rho GTPase regulatory proteins in podocytes
J Matsuda, K Asano-Matsuda, TM Kitzler, T Takano - Kidney International, 2021 - Elsevier
The Rho family of small GTPases (Rho GTPases) are the master regulators of the actin
cytoskeleton and consist of 22 members. Previous studies implicated dysregulation of Rho …
cytoskeleton and consist of 22 members. Previous studies implicated dysregulation of Rho …
Self-organizing feature maps identify proteins critical to learning in a mouse model of down syndrome
C Higuera, KJ Gardiner, KJ Cios - PloS one, 2015 - journals.plos.org
Down syndrome (DS) is a chromosomal abnormality (trisomy of human chromosome 21)
associated with intellectual disability and affecting approximately one in 1000 live births …
associated with intellectual disability and affecting approximately one in 1000 live births …
Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney
disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20 …
disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20 …
Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome
MJ Alldred, H Pidikiti, KW Ibrahim, SH Lee… - Acta …, 2024 - Springer
We elucidated the molecular fingerprint of vulnerable excitatory neurons within select
cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and …
cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and …
A crosstalk between circular RNA, microRNA, and messenger RNA in the development of various brain cognitive disorders
L He, F Zhang, Y Zhu, M Lu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Patients with Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury
(TBI), stroke, and postoperative neurocognitive disorder (POND) are commonly faced with …
(TBI), stroke, and postoperative neurocognitive disorder (POND) are commonly faced with …
Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
JC Cossec, J Lavaur, DE Berman… - Human molecular …, 2012 - academic.oup.com
Enlarged early endosomes have been observed in neurons and fibroblasts in Down
syndrome (DS). These endosome abnormalities have been implicated in the early …
syndrome (DS). These endosome abnormalities have been implicated in the early …
Hypoxia-induced alternative splicing in endothelial cells
Background Adaptation to low oxygen by changing gene expression is vitally important for
cell survival and tissue development. The sprouting of new blood vessels, initiated from …
cell survival and tissue development. The sprouting of new blood vessels, initiated from …
Intersectin—many facets of a scaffold protein
M Mintoo, V Rajagopalan… - Biochemical Society …, 2024 - portlandpress.com
Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions
including regulation of endocytosis, vesicle transport, and activation of various signal …
including regulation of endocytosis, vesicle transport, and activation of various signal …
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular …
Abstract Background The Ts1Cje mouse model of Down syndrome (DS) has partial
triplication of mouse chromosome 16 (MMU16), which is partially homologous to human …
triplication of mouse chromosome 16 (MMU16), which is partially homologous to human …