The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation
and has a well-recognized role in cardiorespiratory regulation. The CB contains …

Acute cardiorespiratory responses to O2 deficiency are essential for physiological
homeostasis. The prototypical acute O2-sensing organ is the carotid body, which contains …

Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments
or medical conditions with restricted exchange of gases in the lung. The main acute O2 …

The carotid body (CB) is a bilateral arterial chemoreceptor located in the carotid artery
bifurcation with an essential role in cardiorespiratory homeostasis. It is composed of highly …

The molecular underpinnings of the oxygen sensitivity of the carotid body Type I cells are
becoming better defined as research begins to identify potential interactions between …

Oxygen (O2) is essential for life and therefore the supply of sufficient O2 to the tissues is a
major physiological challenge. In mammals, a deficit of O2 (hypoxia) triggers rapid …

AMP-activated protein kinase (AMPK) is a ubiquitously expressed metabolic sensor among
various species. Specifically, cellular AMPK is phosphorylated and activated under certain …

The hypoxic ventilatory response (HVR) is critical to breathing and thus oxygen supply to the
body and is primarily mediated by the carotid bodies. Here we reveal that carotid body …

It is generally acknowledged that the carotid body (CB) type I cell mitochondria are unique,
being inhibited by relatively small falls in PaO2 well above those known to inhibit electron …