Tumorigenesis has long been thought to be a multistep process (Foulds, 1958); however,
only recently has it become possible to identify the molecular events that underlie the …

Neurofibromatosis type 2 is an autosomal-dominant multiple neoplasia syndrome that
results from mutations in the NF2 tumour suppressor gene located on chromosome 22q. It …

Abstract Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the
occurrence of bilateral vestibular schwannomas and other central nervous system tumors …

For the past decade, cellular oncogenes have attracted the attention of biologists intent on
understanding the molecular origins of cancer. As the present decade unfolds, oncogenes …

Schwannomas may occur spontaneously, or in the context of a familial tumor syndrome such
as neurofibromatosis type 2 (NF 2), schwannomatosis and C arney's complex …

Small cell lung cancer (SCLC) has been associated with loss of heterozygosity at several
distinct genetic loci including chromosomes 3p, 13q, and 17p. To determine whether the …

More than 20 different hereditary cancer syndromes have now been defined and attributed
to specific germline mutations in various inherited cancer genes. Collectively, the syndromes …

To determine the spectrum of manifestations in neurofibromatosis 2 (NF2) and to assess
possible heterogeneity, we evaluated 63 affected individuals from 32 families. Work‐up …

Malignant mesotheliomas (MMs) are aggressive tumors that develop most frequently in the
pleura of patients exposed to asbestos. In contrast to many other cancers, relatively few …

The clonal composition of human colorectal tumors was studied by means of restriction
fragment length polymorphisms (RFLPs). First, X-linked RFLPs were used to examine the …