XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury
Z Liu, M Wang, X Wang, Q Bu, Q Wang, W Su, L Li… - Redox Biology, 2022 - Elsevier
Hepatocellular cell death and macrophage proinflammatory activation contribute to the
pathology of various liver diseases, during which XBP1 plays an important role. However …
pathology of various liver diseases, during which XBP1 plays an important role. However …
Role of endoplasmic reticulum stress in hepatic glucose and lipid metabolism and therapeutic strategies for metabolic liver disease
W Zheng, Q Sun, L Li, Y Cheng, Y Chen, M Lv… - International …, 2022 - Elsevier
The endoplasmic reticulum is the most abundant membrane organelle in eukaryotic cells. It
is an important site of membrane and secretory protein folding and glycolipid synthesis and …
is an important site of membrane and secretory protein folding and glycolipid synthesis and …
Involvement of endoplasmic reticulum stress in rifampicin-induced liver injury
W Hou, B Nsengimana, C Yan, B Nashan… - Frontiers in …, 2022 - frontiersin.org
Rifampicin is a first-line antituberculosis drug. Hepatocyte toxicity caused by rifampicin is a
significant clinical problem. However, the specific mechanism by which rifampicin causes …
significant clinical problem. However, the specific mechanism by which rifampicin causes …
ER Ca2+ overload activates the IRE1α signaling and promotes cell survival
S Zhao, H Feng, D Jiang, K Yang, ST Wang, YX Zhang… - Cell & Bioscience, 2023 - Springer
Abstract Background Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum
(ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ …
(ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ …
Expression of unfolded protein response genes in post-transplantation liver biopsies
X Liu, SA Taylor, S Celaj, J Levitsky, RM Green - BMC gastroenterology, 2022 - Springer
Background Cholestatic liver diseases are a major source of morbidity and mortality that can
progress to end-stage liver disease and hyperbilirubinemia is a hallmark of cholestasis …
progress to end-stage liver disease and hyperbilirubinemia is a hallmark of cholestasis …
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null mice leads to enhanced liver injury
X Liu, M Khalafalla, C Chung, Y Gindin, S Hubchak… - Journal of lipid …, 2022 - ASBMB
FXR regulates bile acid metabolism, and FXR null (Fxr−/−) mice have elevated bile acid
levels and progressive liver injury. The inositol-requiring enzyme 1α/X-box binding protein 1 …
levels and progressive liver injury. The inositol-requiring enzyme 1α/X-box binding protein 1 …
Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants
A Kriegermeier, A Hyon, B LeCuyer, S Hubchak, X Liu… - PloS one, 2022 - journals.plos.org
Background Increased intrahepatic bile acids cause endoplasmic reticulum (ER) stress and
the unfolded protein response (UPR) is activated to maintain homeostasis. UPR …
the unfolded protein response (UPR) is activated to maintain homeostasis. UPR …
Decoding Pediatric Hepatitis: A Nurse's Handbook
AR Mansur, H Hermalinda - 2024 - repository.penerbiteureka.com
Abstrak" Decoding Pediatric Hepatitis: A Nurse's Handbook" serves as a comprehensive
resource tailored specifically for healthcare professionals, especially nurses, seeking to …
resource tailored specifically for healthcare professionals, especially nurses, seeking to …
IRE1α/XBP1 pathway expression is impaired in pediatric cholestatic liver disease explants
A Kriegermeier, A Hyon, B LeCuyer, S Hubchak, X Liu… - bioRxiv, 2022 - biorxiv.org
Abstract Background/Aims Cholestatic liver diseases (CLD) are the leading indication for
pediatric liver transplantation. Increased intrahepatic bile acid concentrations cause …
pediatric liver transplantation. Increased intrahepatic bile acid concentrations cause …