Aggregation of highly phosphorylated tau into aggregated forms such as filaments and
neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer's disease …

Frontotemporal lobar degeneration (FTLD) has been associated with toxic intracellular
aggregates of hyperphosphorylated tau (FTLD‐tau). Moreover, genetic studies identified …

Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene
as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE …

The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of
Alzheimer's disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting …

Increased Tau protein amyloidogenicity has been causatively implicated in several
neurodegenerative diseases, collectively called tauopathies. In pathological conditions, Tau …

Background A defining pathological hallmark of the progressive neurodegenerative disorder
Alzheimer's disease (AD) is the accumulation of misfolded tau with abnormal post …

Tau is a microtubule-associated binding protein in the nervous system that is known for its
role in stabilizing microtubules throughout the nerve cell. It accumulates as β-sheet-rich …

Abnormal accumulation of the microtubule-interacting protein tau is associated with
neurodegenerative diseases including Alzheimer's disease (AD). β-amyloid (Aβ) lies …

Tau exists as six closely related protein isoforms in the adult human brain. These are
generated from alternative splicing of a single mRNA transcript and they differ in the …

The amyloid-β 42 (Aβ42) peptide has been suggested to promote tau phosphorylation and
toxicity in Alzheimer's disease (AD) pathogenesis; however, the underlying mechanisms are …