Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

How to generate a brain of correct size and with appropriate cell-type diversity during
development is a major question in Neuroscience. In the developing neocortex, radial glial …

Light-sheet fluorescence microscopy (LSFM) is a minimally invasive and high throughput
imaging technique ideal for capturing large volumes of tissue with sub-cellular resolution. A …

The regulation of fate decisions in progenitor cells lays the foundation for the generation of
neuronal diversity and the formation of specialized circuits with remarkable processing …

The central nervous system (CNS) exhibits an extraordinary diversity of neurons, with the
right cell types and proportions at the appropriate sites. Thus, to produce brains with specific …

The seat of human intelligence is the human cerebral cortex, which is responsible for our
exceptional cognitive abilities. Identifying principles that lead to the development of the large …

In the mammalian brain, astrocytes form a heterogeneous population at the morphological,
molecular, functional, intra-, and inter-region levels. In the past, a few types of astrocytes …

Neurodevelopmental disorders are characterized by alterations in the development of the
cerebral cortex, including aberrant changes in the number and function of neural cells …

Tissue clearing renders entire organs transparent to accelerate whole-tissue imaging; for
example, with light-sheet fluorescence microscopy. Yet, challenges remain in analyzing the …

Understanding the generation of complexity in living organisms requires the use of lineage
tracing tools at a multicellular scale. In this review, we describe the different multicolor …