Leishmaniasis is a parasitic neglected tropical disease caused by various species of Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug …
R Abinaya, S Srinath, S Soundarya, R Sridhar… - Journal of Molecular …, 2022 - Elsevier
The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most of these alkaloids and their derivatives have been found to show significant biological …
Leishmaniasis affects more than 12 million humans globally and a further 1 billion people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …
Leishmania, one of the most important neglected tropical diseases, is endemic in several regions of the world and hence regarded as a serious threat to public health. Major …
Y Zhang, Y Shao, J Gong, J Zhu… - The Journal of Organic …, 2019 - ACS Publications
A novel metal-free catalysis protocol for the synthesis of 1, 2-diarylpyrazolo [5, 1-b] quinazolin-9 (1 H)-ones via intramolecular oxidative C–H amination of (E)-3-(arylamino)-2 …
Leishmaniasis affects more than twelve million people globally and a further one billion people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …
In the present study, 45 maleimides have been synthesized and evaluated for anti- leishmanial activities against L. donovani in vitro and cytotoxicity toward THP1 cells. All …
PE Cockram, TK Smith - Journal of natural products, 2018 - ACS Publications
Neglected tropical diseases caused by trypanosomatid parasites are a continuing and escalating problem, which devastate the less economically developed cultures in countries …
Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic nucleus in the field of medicinal chemistry. It has different biological activities like …