[HTML][HTML] Phyto-carbazole alkaloids from the rutaceae family as potential protective agents against neurodegenerative diseases

MA Tan, N Sharma, SSA An - Antioxidants, 2022 - mdpi.com
Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in
the family of Rutaceae (Genera Murraya, Clausena, Glycosmis, Micromelum and …

Recent advancements in anti-leishmanial research: Synthetic strategies and structural activity relationships

O Gupta, T Pradhan, R Bhatia, V Monga - European Journal of Medicinal …, 2021 - Elsevier
Leishmaniasis is a parasitic neglected tropical disease caused by various species of
Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug …

Recent developments on synthesis strategies, SAR studies and biological activities of β-Carboline derivatives–an update

R Abinaya, S Srinath, S Soundarya, R Sridhar… - Journal of Molecular …, 2022 - Elsevier
The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …

Cheminformatics-based discovery of new organoselenium compounds with potential for the treatment of cutaneous and visceral leishmaniasis

FA Ugbe, GA Shallangwa, A Uzairu… - Journal of …, 2023 - Taylor & Francis
Leishmaniasis affects more than 12 million humans globally and a further 1 billion people
are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …

Insights into the current status of privileged N-heterocycles as antileishmanial agents

N Razzaghi-Asl, S Sepehri, A Ebadi, P Karami… - Molecular …, 2020 - Springer
Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …

Selenium-Catalyzed Oxidative C–H Amination of (E)-3-(Arylamino)-2-styrylquinazolin-4 (3 H)-ones: A Metal-Free Synthesis of 1, 2-Diarylpyrazolo [5, 1-b] quinazolin-9 …

Y Zhang, Y Shao, J Gong, J Zhu… - The Journal of Organic …, 2019 - ACS Publications
A novel metal-free catalysis protocol for the synthesis of 1, 2-diarylpyrazolo [5, 1-b]
quinazolin-9 (1 H)-ones via intramolecular oxidative C–H amination of (E)-3-(arylamino)-2 …

Computational evaluation of the inhibitory potential of some urea, thiourea, and selenourea derivatives of diselenides against leishmaniasis: 2D-QSAR …

FA Ugbe, EI Edache, SE Adeniji, DE Arthur… - Journal of Molecular …, 2024 - Elsevier
Leishmaniasis affects more than twelve million people globally and a further one billion
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …

[HTML][HTML] Anti-Leishmanial and cytotoxic activities of a series of maleimides: synthesis, biological evaluation and structure-activity relationship

Y Fan, Y Lu, X Chen, B Tekwani, XC Li, Y Shen - Molecules, 2018 - mdpi.com
In the present study, 45 maleimides have been synthesized and evaluated for anti-
leishmanial activities against L. donovani in vitro and cytotoxicity toward THP1 cells. All …

Active natural product scaffolds against trypanosomatid parasites: a review

PE Cockram, TK Smith - Journal of natural products, 2018 - ACS Publications
Neglected tropical diseases caused by trypanosomatid parasites are a continuing and
escalating problem, which devastate the less economically developed cultures in countries …

[HTML][HTML] Beta-carboline as a promising heterocyclic nucleus: Synthetic aspects, pharmacological potential and structure activity relationship

M Thatikayala, P Wadhwa, P Kaur, PK Singh… - European Journal of …, 2022 - Elsevier
Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic
nucleus in the field of medicinal chemistry. It has different biological activities like …