Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Abstract The European Conference on Infections in Leukemia (ECIL) provides
recommendations for diagnostic strategies and prophylactic, pre-emptive or targeted therapy …

Background Isavuconazole is a novel triazole with broad-spectrum antifungal activity. The
SECURE trial assessed efficacy and safety of isavuconazole versus voriconazole in patients …

Abstract The European Society for Clinical Microbiology and Infectious Diseases, the
European Confederation of Medical Mycology and the European Respiratory Society Joint …

Invasive aspergillosis (IA) in haematology/oncology patients presents as primary infection or
breakthrough infection, which can become refractory to antifungal treatment and has a high …

Azole resistance is a concern for the management of diseases caused by Aspergillus
fumigatus in humans. Azole fungicide use in the environment has been identified as a …

Scope Presenting symptoms, distributions and patterns of diseases and vulnerability to
invasive aspergillosis (IA) are similar between children and adults. However, differences …

This review compares the pharmacology, spectrum of antifungal activity, pharmacokinetic
and pharmacodynamic properties, safety and clinical efficacy of the three licensed …