Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …

Summary Background The polymorphic CYP2D6 enzyme metabolises the antipsychotic
drugs risperidone and aripiprazole to their active metabolites, 9OH-risperidone and …

Pharmacogenomics is a key component of personalized medicine that promises safer and
more effective drug treatment by individualizing drug choice and dose based on genetic …

In recent decades, very few new psychiatric drugs have entered the market. Thus,
improvement in the use of antidepressant and antipsychotic therapy has to focus mainly on …

There are significant differences between men and women in the efficacy and tolerability of
antipsychotic drugs. Here, we provide a comprehensive overview of what is currently known …

Abstract CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved
in the metabolism of around 30% of all medications. Importantly, the corresponding genes …

Pharmacogenomics (PGx) enables personalized treatment for the prediction of drug
response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic …

Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

Vanderbilt University Medical Center implemented pharmacogenomics (PGx) testing with
the Pharmacogenomic Resource for Enhanced Decisions in Care and Treatment …