The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is
synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) …

Abstract Aims Angiotensin II (AngII) is involved in extracellular matrix (ECM) accumulation
contributing to heart failure. Periostin, a 90 kDa ECM protein, is a key regulator of cardiac …

Smaller-scale evaluations suggest that common genetic variation in candidate genes
related to immune function may predispose to the development of non-Hodgkin lymphoma …

Endothelial cells actively participate in inflammatory events by regulating leukocyte
recruitment via the expression of inflammatory genes such as E-selectin, VCAM-1, ICAM-1 …

IL-6 was found to be overexpressed in the adipose tissue of obese individuals, which may
cause insulin resistance. However, the regulation of IL-6 in adipocytes in obesity setting …

WNT1-inducible signaling pathway protein-1 (WISP1), a member of the CYR61/CTGF/Nov
family of growth factors, can mediate cell growth, transformation, and survival. Previously we …

Introduction Human Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive
properties on CD4+ effector T cells by a mechanism partially dependent on GZMB …

Proinflammatory cytokines such as TNFα mediate airway inflammation. Previously, we
showed that TNFα increases mitochondrial biogenesis in human ASM (hASM) cells, which is …

One of the most important challenges that cardiomyocytes experience is an increase in the
levels of reactive oxygen species (ROS), ie, during ischemia, reperfusion as well as in the …