Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …

Impaired macroautophagy/autophagy and high levels of glycolysis are prevalent in liver
cancer. However, it remains unknown whether there is a regulatory relationship between …

The endolysosomal system is critical for the maintenance of cellular homeostasis. However,
how endolysosomal compartment is regulated by mitochondrial function is largely unknown …

Severe combined immunodeficiencies (SCIDs) comprise a group of rare, monogenic
diseases that are characterized by an early onset and a profound block in the development …

Different types of autophagy coexist in most mammalian cells, and each of them fulfills very
specific tasks in intracellular degradation. Some of these autophagic pathways contribute to …

Molecular dissection of inborn errors of immunity can help to elucidate the nonredundant
functions of individual genes. We studied 3 children with an immune dysregulation …

Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune
system and represent 2 sides of the same coin. Multiple single-gene defects have been …

Hexokinase II (HK2), a key enzyme involved in glucose metabolism, is regulated by growth
factor signaling and is required for initiation and maintenance of tumors. Here we show that …

ABSTRACT Chaperone-mediated autophagy (CMA), a selective form of protein lysosomal
degradation, is maximally activated in stress situations to ensure maintenance of cellular …