Mendelian and complex genetic trait diseases continue to burden and affect society both
socially and economically. The lack of effective tests has hampered diagnosis thus, the …

Type 2 diabetes has a global prevalence, with epidemiological data suggesting that some
populations have a higher risk of developing this disease. However, to date, most genetic …

Genetic associations for lipid traits have identified hundreds of variants with clear differences
across European, Asian and African studies. Based on a sub-Saharan-African GWAS for …

Background The emergence of high throughput technologies that produce vast amounts of
genomic data, such as next-generation sequencing (NGS) is transforming biological …

Workflow management systems represent, manage, and execute multistep computational
analyses and offer many benefits to bioinformaticians. They provide a common language for …

Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases
(CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility …

While there are lighthouse examples of microbiome research in sub-Saharan Africa (SSA), a
significant proportion of local researchers face several challenges. Here, we highlight …

With the development of single-cell RNA sequencing (scRNA-seq) technology, it has
become possible to perform large-scale transcript profiling for tens of thousands of cells in a …

Background Genome-wide association studies (GWAS) and phenome-wide association
studies (PheWAS) involving 1 million GWAS samples from dozens of population-based …

Background Genome-wide association studies (GWAS) are a powerful method to detect
associations between variants and phenotypes. A GWAS requires several complex …