Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

Sepsis is the major cause of acute kidney injury (AKI) associated with high mortality rates.
Mitochondrial dysfunction contributes to the pathophysiology of septic AKI. Mitophagy is an …

Acute kidney injury (AKI) is common in critically ill patients and is associated with increased
morbidity and mortality. Dysfunction of other organs is an important cause of poor outcomes …

Cardiovascular Consequences of Acute Kidney Injury Acute kidney injury is associated with
many short-and long-term adverse events. This review considers the cardiovascular …

The kidney is a vital organ that demands an extraordinary amount of energy to actively
maintain the body's metabolism, plasma hemodynamics, electrolytes and water …

Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …

Acute kidney injury (AKI) occurs in about half of critically ill patients and is associated with
high in-hospital mortality, increased long-term mortality postdischarge, and subsequent …

Mitochondrial fission is important in physiological processes, including coordination of
mitochondrial and nuclear division during mitosis, and pathologic processes, such as the …