Experimental models of acute kidney injury for translational research

NA Hukriede, DE Soranno, V Sander… - Nature Reviews …, 2022 - nature.com
Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Mitochondrial metabolism in aging heart

EJ Lesnefsky, Q Chen, CL Hoppel - Circulation research, 2016 - Am Heart Assoc
Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

[HTML][HTML] The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury

Y Wang, J Zhu, Z Liu, S Shu, Y Fu, Y Liu, J Cai, C Tang… - Redox biology, 2021 - Elsevier
Sepsis is the major cause of acute kidney injury (AKI) associated with high mortality rates.
Mitochondrial dysfunction contributes to the pathophysiology of septic AKI. Mitophagy is an …

Distant organ dysfunction in acute kidney injury: a review

SA Lee, M Cozzi, EL Bush, H Rabb - American journal of kidney diseases, 2018 - Elsevier
Acute kidney injury (AKI) is common in critically ill patients and is associated with increased
morbidity and mortality. Dysfunction of other organs is an important cause of poor outcomes …

Cardiovascular consequences of acute kidney injury

M Legrand, P Rossignol - New England Journal of Medicine, 2020 - Mass Medical Soc
Cardiovascular Consequences of Acute Kidney Injury Acute kidney injury is associated with
many short-and long-term adverse events. This review considers the cardiovascular …

Mitochondria damage and kidney disease

P Duann, PH Lin - Mitochondrial Dynamics in cardiovascular medicine, 2017 - Springer
The kidney is a vital organ that demands an extraordinary amount of energy to actively
maintain the body's metabolism, plasma hemodynamics, electrolytes and water …

[HTML][HTML] Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets

K Doi, H Rabb - Kidney international, 2016 - Elsevier
Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

Mitochondria: a therapeutic target in acute kidney injury

Y Ishimoto, R Inagi - Nephrology Dialysis Transplantation, 2016 - academic.oup.com
Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …

Acute kidney injury and distant organ dysfunction–network system analysis

R Matsuura, K Doi, H Rabb - Kidney international, 2023 - Elsevier
Acute kidney injury (AKI) occurs in about half of critically ill patients and is associated with
high in-hospital mortality, increased long-term mortality postdischarge, and subsequent …

Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion …

D Wu, A Dasgupta, KH Chen… - The FASEB …, 2020 - Wiley Online Library
Mitochondrial fission is important in physiological processes, including coordination of
mitochondrial and nuclear division during mitosis, and pathologic processes, such as the …