Single-cell transcriptome analysis in plants: advances and challenges
The rapid and enthusiastic adoption of single-cell RNA sequencing (scRNA-seq) has
demonstrated that this technology is far more than just another way to perform transcriptome …
demonstrated that this technology is far more than just another way to perform transcriptome …
Critical period regulation across multiple timescales
Brain plasticity is dynamically regulated across the life span, peaking during windows of
early life. Typically assessed in the physiological range of milliseconds (real time), these …
early life. Typically assessed in the physiological range of milliseconds (real time), these …
Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development
Both transcription and three-dimensional (3D) architecture of the mammalian genome play
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons
Myelin plasticity occurs when newly formed and pre-existing oligodendrocytes remodel
existing patterns of myelination. Myelin remodeling occurs in response to changes in …
existing patterns of myelination. Myelin remodeling occurs in response to changes in …
Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads
FV De Rop, JN Ismail, CB González-Blas… - Elife, 2022 - elifesciences.org
Single-cell RNA-seq and single-cell assay for transposase-accessible chromatin (ATAC-
seq) technologies are used extensively to create cell type atlases for a wide range of …
seq) technologies are used extensively to create cell type atlases for a wide range of …
Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial
G Maynard, R Kannan, J Liu, W Wang… - The Lancet …, 2023 - thelancet.com
Background Spinal cord injury (SCI) causes neural disconnection and persistent
neurological deficits, so axon sprouting and plasticity might promote recovery. Soluble Nogo …
neurological deficits, so axon sprouting and plasticity might promote recovery. Soluble Nogo …
The maize single-nucleus transcriptome comprehensively describes signaling networks governing movement and development of grass stomata
The unique morphology of grass stomata enables rapid responses to environmental
changes. Deciphering the basis for these responses is critical for improving food security …
changes. Deciphering the basis for these responses is critical for improving food security …
Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
ML Richter, IK Deligiannis, K Yin, A Danese… - Nature …, 2021 - nature.com
Single-cell RNA-seq reveals the role of pathogenic cell populations in development and
progression of chronic diseases. In order to expand our knowledge on cellular …
progression of chronic diseases. In order to expand our knowledge on cellular …
[HTML][HTML] Shifting developmental trajectories during critical periods of brain formation
N Dehorter, I Del Pino - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Research on critical periods of brain development is greatly expanding our understanding of
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …
Single-cell RNA-sequencing of mammalian brain development: insights and future directions
E Vinsland, S Linnarsson - Development, 2022 - journals.biologists.com
Understanding human brain development is of fundamental interest but is also very
challenging. Single-cell RNA-sequencing studies in mammals have revealed that brain …
challenging. Single-cell RNA-sequencing studies in mammals have revealed that brain …