B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T
cell responses remains controversial. However, new data showing that the transient …

Lineage-committed effector CD4+ T cells are generated at the peak of the primary response
and are followed by heterogeneous populations of central and effector memory cells. Here …

Listeria monocytogenes infection generates T helper 1 (Th1) effector memory cells and CC
chemokine receptor 7 (CCR7)+ cells resembling central memory cells. We tracked …

Tumor-infiltrating CD8+ T cells are strongly associated with patient survival in a wide variety
of human cancers. Less is known about tumor-infiltrating CD20+ B cells, which often …

Abstract Follicular helper CD4 T (Tfh) cells are a distinct type of differentiated CD4 T cells
uniquely specialized for B cell help. In this study, we examined Tfh cell fate commitment …

Mycobacterium tuberculosis remains a major public health burden. It is generally thought
that while B cell-and antibody-mediated immunity plays an important role in host defense …

The role of Ab and B cells in preventing infection is established. In contrast, the role of B cell
responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in …

Co-ordinated interaction between distinct cell types is a hallmark of successful immune
function. A striking example of this is the carefully orchestrated cooperation between helper …

Dysfunction of the immune system can result in damage of the peripheral nervous system.
The immunological mechanisms, which include macrophage infiltration, inflammation and …

Celiac disease (CD) is an increasingly common disease of the small intestine that occurs in
genetically susceptible subjects by ingestion of cereal gluten proteins. Gluten is highly …