Organization and regulation of mitochondrial protein synthesis
Mitochondria are essential organelles of endosymbiotic origin that are responsible for
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …
RNA Degradation in Saccharomyces cerevisae
R Parker - Genetics, 2012 - academic.oup.com
All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …
Nanopore native RNA sequencing of a human poly (A) transcriptome
High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …
understanding of transcriptome complexity and regulation. However, these methods lose …
Replication and transcription of human mitochondrial DNA
M Falkenberg, NG Larsson… - Annual Review of …, 2024 - annualreviews.org
Mammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA
and RNA polymerases, and our understanding of these processes has progressed …
and RNA polymerases, and our understanding of these processes has progressed …
RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release
Mitochondria are essential regulators of innate immunity. They generate long mitochondrial
double-stranded RNAs (mt-dsRNAs) and release them into the cytosol to trigger an immune …
double-stranded RNAs (mt-dsRNAs) and release them into the cytosol to trigger an immune …
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
S Silva, LP Camino, A Aguilera - Proceedings of the …, 2018 - National Acad Sciences
R loops are nucleic acid structures comprising an DNA–RNA hybrid and a displaced single-
stranded DNA. These structures may occur transiently during transcription, playing essential …
stranded DNA. These structures may occur transiently during transcription, playing essential …
RNA granules in the mitochondria and their organization under mitochondrial stresses
VJ Xavier, JC Martinou - International Journal of Molecular Sciences, 2021 - mdpi.com
The human mitochondrial genome (mtDNA) regulates its transcription products in
specialised and distinct ways as compared to nuclear transcription. Thanks to its mtDNA …
specialised and distinct ways as compared to nuclear transcription. Thanks to its mtDNA …
Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies
K Kehrein, R Schilling, BV Möller-Hergt, CA Wurm… - Cell reports, 2015 - cell.com
Mitochondria contain their own genetic system that provides subunits of the complexes
driving oxidative phosphorylation. A quarter of the mitochondrial proteome participates in …
driving oxidative phosphorylation. A quarter of the mitochondrial proteome participates in …
Mitochondrial gene expression and beyond—novel aspects of cellular physiology
AV Kotrys, RJ Szczesny - Cells, 2019 - mdpi.com
Mitochondria are peculiar organelles whose proper function depends on the crosstalk
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …
The human mitochondrial transcriptome and the RNA‐binding proteins that regulate its expression
The human mitochondrial transcriptome, although produced from a small and compact
genome, has revealed surprising complexity in its composition and regulation. Wide …
genome, has revealed surprising complexity in its composition and regulation. Wide …