The use of the nicotine metabolite ratio as a biomarker to personalize smoking cessation treatment: current evidence and future directions
The nicotine metabolite ratio (NMR), a genetically informed biomarker of rate of nicotine
metabolism, has been validated as a tool to select the optimal treatment for individual …
metabolism, has been validated as a tool to select the optimal treatment for individual …
Inhibition of nicotine metabolism by cannabidiol (CBD) and 7-hydroxycannabidiol (7-OH-CBD)
Cannabis-based products have experienced notable increases in co-usage alongside
tobacco products. Several cannabinoids exhibit inhibition of a number of cytochrome P450 …
tobacco products. Several cannabinoids exhibit inhibition of a number of cytochrome P450 …
[HTML][HTML] The impact of rate of nicotine metabolism, as measured by the nicotine metabolite ratio (NMR), on smoking behaviours during pregnancy: A scoping review
Smoking during pregnancy is detrimental to the foetus and the mother, but quitting smoking
can be challenging for pregnant women. The nicotine metabolite ratio (NMR), the ratio …
can be challenging for pregnant women. The nicotine metabolite ratio (NMR), the ratio …
[HTML][HTML] Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status
E Nerpin, DS Ferreira, J Weyler, V Schlunnsen… - World Allergy …, 2021 - Elsevier
Background Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used
both to support diagnosis of asthma and follow up asthma patients. The associations of …
both to support diagnosis of asthma and follow up asthma patients. The associations of …
Characteristic human individual puffing profiles can generate more TNCO than ISO and Health Canada regimes on smoking machine when the same brand is smoked
CGGM Pauwels, AW Boots, WF Visser… - International Journal of …, 2020 - mdpi.com
Human smoking behavior influences exposure to smoke toxicants and is important for risk
assessment. In a prospective observational study, the smoking behavior of Marlboro …
assessment. In a prospective observational study, the smoking behavior of Marlboro …
The novel CYP2A6 inhibitor, DLCI-1, decreases nicotine self-administration in mice
YC Chen, JP Fowler, J Wang, CJW Watson… - … of Pharmacology and …, 2020 - ASPET
During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by
cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been …
cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been …
Nicotine metabolite ratios in serum and urine among US adults: variations across smoking status, gender and race/ethnicity
RB Jain - Biomarkers, 2020 - Taylor & Francis
Purpose: The objective of this study was to evaluate factors affecting variabilities in the
observed levels of nicotine metabolite ratios in serum (NMRS, N= 10,234) and urine (NMRU …
observed levels of nicotine metabolite ratios in serum (NMRS, N= 10,234) and urine (NMRU …
Relationships between the nicotine metabolite ratio and laboratory assessments of smoking reinforcement and craving among adults in a smoking cessation trial
Introduction People who metabolize nicotine more quickly are generally less successful at
quitting smoking. However, the mechanisms that link individual differences in the nicotine …
quitting smoking. However, the mechanisms that link individual differences in the nicotine …
Evaluation of the nicotine metabolite ratio in smoking patients treated with varenicline and bupropion
PRX Tomaz, TS Gonçalves, JR Santos… - Frontiers in …, 2022 - frontiersin.org
Background: Smoking is the leading cause of preventable death worldwide. It is responsible
for several types of cancer, cardiovascular diseases, and diseases of the reproductive …
for several types of cancer, cardiovascular diseases, and diseases of the reproductive …
Variation in nicotine metabolization according to biological factors and type of nicotine consumer
H Pérez-Martín, C Lidón-Moyano, A González-Marrón… - Healthcare, 2023 - mdpi.com
This study aims to describe the nicotine metabolite ratio among tobacco smokers and
electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a …
electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a …