[HTML][HTML] Dopamine signaling and myopia development: what are the key challenges

X Zhou, MT Pardue, PM Iuvone, J Qu - Progress in retinal and eye research, 2017 - Elsevier
In the face of an “epidemic” increase in myopia over the last decades and myopia
prevalence predicted to reach 2.5 billion people by the end of this decade, there is an urgent …

Candidate pathways for retina to scleral signaling in refractive eye growth

DM Brown, R Mazade, D Clarkson-Townsend… - Experimental eye …, 2022 - Elsevier
The global prevalence of myopia, or nearsightedness, has increased at an alarming rate
over the last few decades. An eye is myopic if incoming light focuses prior to reaching the …

The role of ipRGCs in ocular growth and myopia development

AL Liu, YF Liu, G Wang, YQ Shao, CX Yu, Z Yang… - Science …, 2022 - science.org
The increasing global prevalence of myopia calls for elaboration of the pathogenesis of this
disease. Here, we show that selective ablation and activation of intrinsically photosensitive …

Ambient light regulates retinal dopamine signaling and myopia susceptibility

EG Landis, HN Park, M Chrenek, L He… - … & Visual Science, 2021 - iovs.arvojournals.org
Purpose: Exposure to high-intensity or outdoor lighting has been shown to decrease the
severity of myopia in both human epidemiological studies and animal models. Currently, it is …

Dim light exposure and myopia in children

EG Landis, V Yang, DM Brown… - … & visual science, 2018 - iovs.arvojournals.org
Purpose: Experimental myopia in animal models suggests that bright light can influence
refractive error and prevent myopia. Additionally, animal research indicates activation of rod …

Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function

JD Bhoi, M Goel, CP Ribelayga, SC Mangel - Progress in retinal and eye …, 2023 - Elsevier
Abstract Circadian (24-h) clocks are cell-autonomous biological oscillators that orchestrate
many aspects of our physiology on a daily basis. Numerous circadian rhythms in …

[HTML][HTML] Dopaminergic modulation of retinal processing from starlight to sunlight

S Roy, GD Field - Journal of pharmacological sciences, 2019 - Elsevier
Neuromodulators such as dopamine, enable context-dependent plasticity of neural circuit
function throughout the central nervous system. For example, in the retina, dopamine tunes …

Ubiquitous light-emitting diodes: potential threats to retinal circadian rhythms and refractive development

C Zhang, Z Zhu, J Zhao, Y Li, Z Zhang… - Science of The Total …, 2023 - Elsevier
The use of light-emitting diodes (LEDs) has increased considerably in the 21st century with
humans living in a modern photoperiod with brighter nights and dimmer days. Prolonged …

Circadian regulation in the retina: from molecules to network

GYP Ko - European Journal of Neuroscience, 2020 - Wiley Online Library
The mammalian retina is the most unique tissue among those that display robust
circadian/diurnal oscillations. The retina is not only a light sensing tissue that relays light …

Rod photoreceptor activation alone defines the release of dopamine in the retina

V Pérez-Fernández, N Milosavljevic, AE Allen… - Current Biology, 2019 - cell.com
Retinal dopamine is released by a specialized subset of amacrine cells in response to light
and has a potent influence on how the retina responds to, and encodes, visual information …