The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology

C Esser, A Rannug - Pharmacological reviews, 2015 - ASPET
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to
the Per-ARNT-Sim–basic helix-loop-helix protein family. AhR translocates into the nucleus …

Involvement of cytochrome P450 enzymes in inflammation and cancer: a review

MC Stipp, A Acco - Cancer chemotherapy and pharmacology, 2021 - Springer
Cytochrome P450 (CYP) enzymes are responsible for the biotransformation of drugs,
xenobiotics, and endogenous substances. This enzymatic activity can be modulated by …

[HTML][HTML] Bioaccumulation of heavy metals in fish species from the Meiliang Bay, Taihu Lake, China

S Rajeshkumar, X Li - Toxicology reports, 2018 - Elsevier
In the present study, the bioaccumulation of heavy metals (Cr, Cu, Cd, Pb) content were
determined in freshwater edible fishes Cyprinus carpio Linnaeus and Pelteobagrus …

Causes of genome instability: the effect of low dose chemical exposures in modern society

SAS Langie, G Koppen, D Desaulniers… - …, 2015 - academic.oup.com
Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

[PDF][PDF] Liver and cadmium toxicity

VS Arroyo, KM Flores, LB Ortiz… - J Drug Metab …, 2012 - researchgate.net
Cadmium (Cd) is an important environmental pollutant. This metal presents a serious threat
for both, humans and animals health. The environmental risk can lead to the absorption of …

Smart adsorbents for aquatic environmental remediation

E Nazarzadeh Zare, A Mudhoo, M Ali Khan, M Otero… - Small, 2021 - Wiley Online Library
A noticeable interest and steady rise in research studies reporting the design and
assessment of smart adsorbents for sequestering aqueous metal ions and xenobiotics has …

Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?

RN Carvalho, A Arukwe, S Ait-Aissa… - Toxicological …, 2014 - academic.oup.com
The risk posed by complex chemical mixtures in the environment to wildlife and humans is
increasingly debated, but has been rarely tested under environmentally relevant scenarios …

Environmentally relevant concentration of chromium activates Nrf2 and alters transcription of related XME genes in liver of zebrafish

P Shaw, P Mondal, A Bandyopadhyay… - Chemosphere, 2019 - Elsevier
Fish is an excellent model to decipher the mechanism of toxicity of aquatic contaminants
such as hexavalent chromium (Cr [VI]). The present study looked into the manifestation of …

Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: A crucial role for aryl hydrocarbon receptor

S Mohammadi, A Memarian, S Sedighi… - …, 2018 - Taylor & Francis
Macrophages are versatile phagocytic cells in immune system with immunoregulatory
functions. However, the removal of apoptotic cells by macrophages is disturbed in systemic …

Heavy metal contamination in a highly consumed Brazilian fish: immunohistochemical and histopathological assessments

LA Savassi, AL Paschoalini, FP Arantes… - Environmental …, 2020 - Springer
Due to industrial, rural, and domestic waste disposal, heavy metals such as cadmium (Cd),
chromium (Cr), lead (Pb), zinc (Zn), copper (Cu), and iron (Fe) continually infiltrate aquatic …