Bone morphogenetic proteins: facts, challenges, and future perspectives

AC Carreira, FH Lojudice, E Halcsik… - Journal of dental …, 2014 - journals.sagepub.com
Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily, acting as
potent regulators during embryogenesis and bone and cartilage formation and repair. Cell …

[HTML][HTML] Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics

D Rodríguez, CJ Morrison, CM Overall - Biochimica et Biophysica Acta …, 2010 - Elsevier
The biological roles of the matrix metalloproteinases (MMPs) have been traditionally
associated with the degradation and turnover of most of the components of the extracellular …

Bone morphogenetic protein signaling in bone homeostasis

G Sánchez-Duffhues, C Hiepen, P Knaus, P Ten Dijke - Bone, 2015 - Elsevier
Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

N Sotoodehnia, A Isaacs, PIW De Bakker, M Dörr… - Nature …, 2010 - nature.com
The QRS interval, from the beginning of the Q wave to the end of the S wave on an
electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor …

Use and efficacy of bone morphogenetic proteins in fracture healing

SN Lissenberg-Thunnissen, DJJ de Gorter… - International …, 2011 - Springer
Purpose This review evaluates the application of bone morphogenetic proteins (BMPs) in
delayed bone repair, aiming at a broad audience from clinicians to scientists. Next to an …

Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

A Omenetti, A Porrello, Y Jung, L Yang… - The Journal of …, 2008 - Am Soc Clin Investig
Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction
during embryogenesis, and evidence suggests that this process may also help to remodel …

MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling

J Zhang, W Fu, M He, W Xie, Q Lv, G Wan, G Li… - RNA biology, 2011 - Taylor & Francis
Osteogenic differentiation of mesenchymal stem cells (MSCs) is a complex process, which is
regulated by various factors including microRNAs. Our preliminary data showed that the …

[HTML][HTML] Growth factor regulation of lens development

FJ Lovicu, JW McAvoy - Developmental biology, 2005 - Elsevier
Lens arises from ectoderm situated next to the optic vesicles. By thickening and
invaginating, the ectoderm forms the lens vesicle. Growth factors are key regulators of cell …

The extracellular regulation of bone morphogenetic protein signaling

D Umulis, MB O'Connor, SS Blair - Development, 2009 - journals.biologists.com
In many cases, the level, positioning and timing of signaling through the bone
morphogenetic protein (BMP) pathway are regulated by molecules that bind BMP ligands in …

Mosaic genome evolution in a recent and rapid avian radiation

KF Stryjewski, MD Sorenson - Nature Ecology & Evolution, 2017 - nature.com
Recent genomic analyses of evolutionary radiations suggest that ancestral or standing
genetic variation may facilitate rapid diversification, particularly in cases involving …