Objective: The mutation spectrum of the GJB2 and SLC26A4 genes, the 2 most common
genes causing deafness, are known to be ethnic specific. In this study, the spectrum of the …

Mutations in connexins are the most common causes of hearing impairment (HI) in many
populations. Our aim was to review the global burden of pathogenic and likely pathogenic …

Our study aimed to investigate GJB2 (connexin 26) and GJB6 (connexin 30) mutations
associated with non-syndromic childhood hearing impairment (HI) as well as the …

The incidence of hearing impairment (HI) is higher in low-and middle-income countries
when compared to high-income countries. There is therefore a necessity to estimate the …

Introduction Approximately 60% of congenital pediatric hearing loss is of genetic etiology. To
evaluate non-syndromic sensorineural hearing loss (NSSNHL), guidelines emphasize the …

Hearing loss is the most common sensorineural disorder worldwide and is associated with
more than 1000 mutations in more than 90 genes. While mutations in genes such as GJB2 …

This review highlights molecular genetic studies of monogenic traits where common
pathogenic mutations occur in black families from sub-Saharan Africa. Examples of founder …

This study aimed to investigate GJB2 (connexin 26) and GJB6 (connexin 30) mutations
associated with familial non-syndromic childhood hearing impairment (HI) in Cameroon. We …

There is scarcity of known gene variants of hearing impairment (HI) in African populations.
This knowledge deficit is ultimately affecting the development of genetic diagnoses. We …

Origins of all hearing impairment forms may be divided into genetic mutations and acquired
influence. Both carry damage to the inner ear structure resulting in a mild to profound …