Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

D Bertheloot, E Latz, BS Franklin - Cellular & molecular immunology, 2021 - nature.com
Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Pattern recognition receptors in health and diseases

D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism

V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

Pathway paradigms revealed from the genetics of inflammatory bowel disease

DB Graham, RJ Xavier - Nature, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

How autophagy controls the intestinal epithelial barrier

EG Foerster, T Mukherjee, L Cabral-Fernandes… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

A Larabi, N Barnich, HTT Nguyen - Autophagy, 2020 - Taylor & Francis
One of the most significant challenges of inflammatory bowel disease (IBD) research is to
understand how alterations in the symbiotic relationship between the genetic composition of …

Cell death pathways: intricate connections and disease implications

M Kist, D Vucic - The EMBO Journal, 2021 - embopress.org
Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Autophagy and macrophage functions: inflammatory response and phagocytosis

MY Wu, JH Lu - Cells, 2019 - mdpi.com
Autophagy is a conserved bulk degradation and recycling process that plays important roles
in multiple biological functions, including inflammatory responses. As an important …

Selective autophagy and xenophagy in infection and disease

V Sharma, S Verma, E Seranova, S Sarkar… - Frontiers in cell and …, 2018 - frontiersin.org
Autophagy, a cellular homeostatic process, which ensures cellular survival under various
stress conditions, has catapulted to the forefront of innate defense mechanisms during …