The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

O 2 sensing is essential for mammalian homeostasis. Peripheral chemoreceptors such as
the carotid body (CB) contain cells with O 2-sensitive K+ channels, which are inhibited by …

The molecular mechanisms underlying the metabolic shift toward increased glycolysis
observed in pulmonary artery smooth muscle cells (PASMC) during the pathogenesis of …

It is essential to life that a balance is maintained between processes that produce ATP and
those that consume it. An obvious way to do this would be to have systems that monitor the …

Oxygen (O2) is fundamental for cell and whole-body homeostasis. Our understanding of the
adaptive processes that take place in response to a lack of O2 (hypoxia) has progressed …

Pulmonary hypertension (PH) is a debilitating and life-threatening disease characterized by
increased blood pressure within the pulmonary arteries. Adenosine monophosphate …

Key points Uterine artery vasodilatation is a key mechanism for increasing utero‐placental
blood flow and fetal nutrient supply. Since the pioneering work of Joseph Barcroft, the …

Hypoxic chemotransduction in the carotid body requires release of excitatory transmitters
from type I cells that activate afferent sensory neurones. Transmitter release is dependent on …