Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

[HTML][HTML] Drug resistance and combating drug resistance in cancer

X Wang, H Zhang, X Chen - Cancer drug resistance, 2019 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches

TB Emran, A Shahriar, AR Mahmud, T Rahman… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Non-coding RNAs in cancer: Platforms and strategies for investigating the genomic “dark matter”

K Grillone, C Riillo, F Scionti, R Rocca… - Journal of Experimental …, 2020 - Springer
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …

RNAInter in 2020: RNA interactome repository with increased coverage and annotation

Y Lin, T Liu, T Cui, Z Wang, Y Zhang, P Tan… - Nucleic acids …, 2020 - academic.oup.com
Research on RNA-associated interactions has exploded in recent years, and increasing
numbers of studies are not limited to RNA–RNA and RNA–protein interactions but also …

Non-coding RNAs: the new central dogma of cancer biology

PE Saw, X Xu, J Chen, EW Song - Science China Life Sciences, 2021 - Springer
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

Long non-coding RNAs regulate drug resistance in cancer

K Liu, L Gao, X Ma, JJ Huang, J Chen, L Zeng… - Molecular cancer, 2020 - Springer
Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of
cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various …

LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling

S Zhang, H Ma, D Zhang, S Xie, W Wang, Q Li… - Cell death & …, 2018 - nature.com
Numerous findings have demonstrated that long noncoding RNA (lncRNA) dysregulation
plays a key role in many human neoplasms, including tongue squamous cell carcinoma …

NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer

AR Özeş, DF Miller, ON Özeş, F Fang, Y Liu, D Matei… - Oncogene, 2016 - nature.com
The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA
(lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer …

Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells

J Pan, XU Li, W Wu, M Xue, H Hou, W Zhai, W Chen - Cancer letters, 2016 - Elsevier
Chemoresistance constitutes the major failing of clinical therapy for bladder cancer.
However, the molecular mechanisms involved in the chemoresistance of bladder cancer are …