Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …

Epigenetic regulation plays an important role in the occurrence, development and treatment
of malignant tumors; and a great deal of attention has been paid to the histone methylation …

The DNA guanine quadruplexes (G4) play important roles in multiple cellular processes,
including DNA replication, transcription and maintenance of genome stability. Here, we …

Glucose is a universal bioenergy source; however, its role in controlling protein interactions
is unappreciated, as are its actions during differentiation-associated intracellular glucose …

Cuproptosis is a newly discovered cell death induced by excessive copper in mitochondria
distinct from any known forms of apoptosis. Role of cuproptosis has not been well-reported …

Histone marks control many cellular processes including DNA damage repair. This review
will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage …

Clear cell renal cell carcinoma (ccRCC) is a common aggressive malignant tumor of the
urinary system. Given the heterogeneity of the tumor microenvironment, immunotherapy may …

Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high
incidence rate. Circular RNAs (circRNAs) are noncoding RNAs with widespread distribution …

SET domain-containing 2 (SETD2) is a lysine methyltransferase that catalyzes histone H3
lysine36 trimethylation (H3K36me3) and has been revealed to play important roles in the …

Unlike early clear cell renal cell carcinoma (ccRCC), locally advanced and metastatic
ccRCC present poor treatment outcomes and prognosis. As immune checkpoint inhibitors …