Abstract Sensory Processing Sensitivity (SPS) is a common, heritable and evolutionarily
conserved trait describing inter-individual differences in sensitivity to both negative and …

Current research supports the notion that the apparently innate trait Sensory Processing
Sensitivity (SPS) may act as a modulator of development as function of the environment …

Background Besides chronic stress, chronic pain is a prevalent determinant for depression.
Changes induced in specific brain regions by sustained pain may alter the processing of …

Posttraumatic stress disorder (PTSD) is a common anxiety disorder characterised by its
persistence of symptoms after a traumatic experience. Although some patients can be cured …

Rodent defense behavior assays have been widely used as preclinical models of anxiety to
study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety …

Serotonin, in its function as neurotransmitter, is well-known for its role in depression, autism
and other neuropsychiatric disorders, however, less known as a neurodevelopmental factor …

Decision-making plays a pivotal role in daily life as impairments in processes underlying
decision-making often lead to an inability to make profitable long-term decisions. As a case …

Neural activity is essential for the maturation of sensory systems. In the rodent primary
somatosensory cortex (S1), high extracellular serotonin (5-HT) levels during development …

In analogy with the accepted view that behaviour is shaped by gene× environment (G× E)
interactions, G× E studies are exponentially increasing in the field of psychiatry. Whereas …

There is high consensus that stress-related disorders like depression are shaped by nature×
nurture interactions. However, the complexity appears larger than envisaged and nature× …