Gas cluster ion beams for secondary ion mass spectrometry
N Winograd - Annual review of analytical chemistry, 2018 - annualreviews.org
Gas cluster ion beams (GCIBs) provide new opportunities for bioimaging and molecular
depth profiling with secondary ion mass spectrometry (SIMS). These beams, consisting of …
depth profiling with secondary ion mass spectrometry (SIMS). These beams, consisting of …
Using mass spectrometry imaging to visualize age-related subcellular disruption
Metabolic homeostasis balances the production and consumption of energetic molecules to
maintain active, healthy cells. Cellular stress, which disrupts metabolism and leads to the …
maintain active, healthy cells. Cellular stress, which disrupts metabolism and leads to the …
ToF-SIMS Depth Profiling of Metal, Metal Oxide, and Alloy Multilayers in Atmospheres of H2, C2H2, CO, and O2
J Ekar, P Panjan, S Drev, J Kovač - Journal of the American …, 2021 - ACS Publications
The influence of the flooding gas during ToF-SIMS depth profiling was studied to reduce the
matrix effect and improve the quality of the depth profiles. The profiles were measured on …
matrix effect and improve the quality of the depth profiles. The profiles were measured on …
Recent advances in mass spectrometry imaging of single cells
J Liu, W Hu, Y Han, H Nie - Analytical and Bioanalytical Chemistry, 2023 - Springer
Mass spectrometry imaging (MSI) is a sensitive, specific, label-free imaging analysis
technique that can simultaneously obtain the spatial distribution, relative content, and …
technique that can simultaneously obtain the spatial distribution, relative content, and …
CO2 Cluster Ion Beam, an Alternative Projectile for Secondary Ion Mass Spectrometry
The emergence of argon-based gas cluster ion beams for SIMS experiments opens new
possibilities for molecular depth profiling and 3D chemical imaging. These beams generally …
possibilities for molecular depth profiling and 3D chemical imaging. These beams generally …
Improvement of biomolecular analysis in thin films using in situ matrix enhanced secondary ion mass spectrometry
Sensitivity to molecular ions remains a limiting factor for high resolution imaging mass
spectrometry of organic and biological materials. Here, we investigate a variant of matrix …
spectrometry of organic and biological materials. Here, we investigate a variant of matrix …
Reducing the matrix effect in organic cluster SIMS using dynamic reactive ionization
H Tian, A Wucher, N Winograd - … of The American Society for Mass …, 2016 - ACS Publications
Dynamic reactive ionization (DRI) utilizes a reactive molecule, HCl, which is doped into an
Ar cluster projectile and activated to produce protons at the bombardment site on the cold …
Ar cluster projectile and activated to produce protons at the bombardment site on the cold …
SIMS of delta layers in organic materials: amount of substance, secondary ion species, matrix effects, and anomalous structures in argon gas cluster depth profiles
A study is reported of the quantification of the amount of matter by secondary ion mass
spectrometry (SIMS) when depth profiling a nominally 3.1 nm thick delta layer of FMOC-l …
spectrometry (SIMS) when depth profiling a nominally 3.1 nm thick delta layer of FMOC-l …
Automated Single Cell Phenotyping of Time-of-Flight Secondary Ion Mass Spectrometry Tissue Images
S Bajaj, S Tolleson, A Zarfeshani, M Hav… - Journal of the …, 2024 - ACS Publications
Existing analytical techniques are being improved or applied in new ways to profile the
tissue microenvironment (TME) to better understand the role of cells in disease research …
tissue microenvironment (TME) to better understand the role of cells in disease research …
CO Bond Dissociation and Induced Chemical Ionization Using High Energy (CO2)n+ Gas Cluster Ion Beam
A gas cluster ion beam (GCIB) source, consisting of CO 2 clusters and operating with kinetic
energies of up to 60 keV, has been developed for the high resolution and high sensitivity …
energies of up to 60 keV, has been developed for the high resolution and high sensitivity …