The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter
release and in triggering alterations in neuronal function. Calmodulin has been widely …

FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS …

Mutations in presenilin genes account for the majority of the cases of the familial form of
Alzheimer's disease (FAD). Presenilin is essential for γ-secretase activity, a proteolytic …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical
component of the ensemble of voltage-gated ionic currents that determine somatodendritic …

Although many studies have addressed the regulatory circuits affecting neuronal activities,
local non-synaptic mechanisms that determine neuronal excitability remain unclear. Here …

Importance While numerous genetic susceptibility loci have been identified for clinical
Alzheimer disease (AD), it is important to establish whether these variants are risk factors for …

Voltage-gated potassium (Kv) channels from the Kv4, or Shal-related, gene family underlie a
major component of the A-type potassium current in mammalian central neurons. We …