The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Poly (ADP-ribosyl) ation (PARylation) is an essential post-translational modification
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …

Abstract Poly (ADP‐ribose) polymerase (PARP) has been proposed to play an important
role in the pathogenesis of heart ischaemia/reperfusion (I/R) injury. However, the …

Poly (ADP-ribose) polymerases (PARP) comprise a family of enzymes which catalyse poly
(ADP-ribosyl) ation of DNA-binding proteins. Multiple researches indicate the importance of …

Dual‐specificity protein phosphatases (DUSP) also known as mitogen‐activated protein
kinase (MAPK) phosphatases (MKPs) can dephosphorylate MAPKs, including extracellular …

Necrotic lesions and necrotic cell death characterize severe autoimmune nephritides, and
contribute to local inflammation and to progression of the disease. Poly (ADP-ribose) …

The poly (ADP-ribose) polymerases (PARPs) catalyse the transfer of ADP-ribose units from
the substrate NAD+ to acceptor proteins, biosynthesising polyanionic poly (ADP-ribose) …

Abstract Background and Purpose Olaparib, rucaparib and niraparib, potent inhibitors of
poly (ADP‐ribose) polymerase (PARP) are approved as anti‐cancer drugs in humans …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage.
PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative …

Sound can damage peripheral cochlear function through a number of mechanisms, and
emerging evidence suggests that inflammation may be one of them. Using …