Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
A review on cholinesterase inhibitors for Alzheimer's disease
P Anand, B Singh - Archives of pharmacal research, 2013 - Springer
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in …
characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in …
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease
Q Li, H Yang, Y Chen, H Sun - European journal of medicinal chemistry, 2017 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease
Q Li, S He, Y Chen, F Feng, W Qu, H Sun - European journal of medicinal …, 2018 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl-and butyryl …
The multifunctional nature of Alzheimer's disease calls for MTDLs (multitarget-directed
ligands) to act on different components of the pathology, like the cholinergic dysfunction and …
ligands) to act on different components of the pathology, like the cholinergic dysfunction and …
Neurobiology of butyrylcholinesterase
S Darvesh, DA Hopkins, C Geula - Nature Reviews Neuroscience, 2003 - nature.com
Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the
hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique …
hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique …
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …
Current issues in organophosphate toxicology
LG Costa - Clinica chimica acta, 2006 - Elsevier
Organophosphates (OPs) are one of the main classes of insecticides, in use since the mid
1940s. OPs can exert significant adverse effects in non-target species including humans …
1940s. OPs can exert significant adverse effects in non-target species including humans …