The tumor microenvironment is a dynamic, complex, and redundant network of interactions
between tumor, immune, and stromal cells. In this intricate environment, cells communicate …

The immune checkpoint blockade-based immunotherapies are revolutionizing cancer
management. Tumor-associated neutrophils (TANs) were recently highlighted to have a …

Background The risk factors for immune-related adverse events (irAEs) remain undefined.
Recently, a correlation between irAEs and clinical benefit was suggested. We examined the …

Background The systemic immune‐inflammation index (SII) is correlated with patient
survival in various types of solid tumors. However, only a few studies have focused on the …

Background: Colorectal cancer (CRC) is the third most common cancer and it is a worldwide
challenge. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) had …

Haemogram assessment is a cheap and easy method which can be readily performed for
almost all patients. Leucocyte, neutrophil and lymphocyte counts and the neutrophil to …

Background: Lung neuroendocrine carcinoma (NEC) is characterized by aggressive clinical
behavior and lack of treatment advances. We evaluate the prognostic and the predictive …

Background Inflammation scores based on general inflammation markers as leucocyte
count or C-reactive protein have been evaluated as prognostic markers of inferior survival in …

Introduction: Acute limb ischemia (ALI), classified according to Rutherford's classification
(RC), is a vascular emergency burdened by high rates of mortality and morbidity. The need …

Background We evaluated pretreatment total lymphocyte count (TLC, marker of
immunosuppression), neutrophil-to-lymphocyte ratio (NLR, marker of inflammation), and …