We review the hemodynamic, metabolic and cellular parameters affected during early
ischemia and their changes as a function of approximate cerebral blood flow (CBF) …

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO 2) are
key cerebral physiological parameters to identify at-risk cerebrovascular patients and …

The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Purpose The development of a reliable clinical technique for quantitative measurements of
the parameters defining the BOLD effect, ie, oxygen extraction fraction (OEF), and …

The brain depends almost entirely on oxidative metabolism to meet its significant energy
requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key …

Purpose Our objective was to demonstrate the feasibility of using hyperventilation as an
efficient vasoconstrictive challenge and prior knowledge as denoising constraints for …

Gaining insights into brain oxygen metabolism has been one of the key areas of research in
neurosciences. Extensive efforts have been devoted to developing approaches capable of …

Quantitative susceptibility mapping (QSM) is a promising non-invasive method for obtaining
information relating to oxygen metabolism. However, the optimal acquisition sequence and …

New MRI methods for noninvasive imaging of baseline oxygen extraction fraction (OEF) in
the brain show great promise. Quantitative O 2 imaging (QUO2) applies a biophysical model …

This article provides an overview of MRI methods exploiting magnetic susceptibility
properties of blood to assess cerebral oxygen metabolism, including the tissue oxygen …