Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …

Early studies have shown how aberrantly expressed microRNAs are a hallmark of several
diseases like cancer. MicroRNA expression profiling was shown to be associated with …

Immune checkpoint blockade (ICB) has revolutionized cancer therapeutics. Desmoplastic
malignancies, such as cholangiocarcinoma (CCA), have an abundant tumor immune …

Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative
stress when it was first linked to mutant superoxide dismutase 1 (SOD1). The subsequent …

De novo and acquired resistance, which are largely attributed to genetic alterations, are
barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate …

The blood-brain barrier (BBB) is crucial to the health of the brain and is often compromised
in neurological disease. Moreover, because of its barrier properties, this endothelial …

Background Acquired resistance to sorafenib greatly limits its therapeutic efficiency in the
treatment of hepatocellular carcinoma (HCC). Increasing evidence indicates that long …

Purpose: Our goal was to identify circulating micro RNA (miRNA) levels that could
distinguish patients with low-stage pancreatic cancer from healthy and disease controls …

Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory
cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally …

Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown
etiopathogenesis. Here we tested the hypothesis that cholangiocyte senescence is a …