Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase that
polyubiquitinates specific substrates at precise times in the cell cycle, thereby triggering the …

Animal cells undergo dramatic changes in shape, mechanics and polarity as they progress
through the different stages of cell division. These changes begin at mitotic entry, with cell …

The ultimate goal of cell division is equal transmission of the duplicated genome to two new
daughter cells. Multiple surveillance systems exist that monitor proper execution of the cell …

Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved
before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the …

The ubiquitin proteasome system (UPS) directs programmed destruction of key cellular
regulators via posttranslational modification of its targets with polyubiquitin chains. These …

The Aurora kinases are essential regulators of mitosis in eukaryotes. In somatic cell
divisions of higher eukaryotes, the paralogs Aurora kinase A (AurA) and Aurora kinase B …

The actin cytoskeleton and adhesion junctions are physically and functionally coupled at the
cell–cell interface between epithelial cells. The actin regulatory complex Arp2/3 has an …

In many tissues, the stem cell niche must coordinate behavior across multiple stem cell
lineages. How this is achieved is largely unknown. We have identified delayed completion of …

Targeted protein degradation tools are becoming a new therapeutic modality, allowing small
molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting …