Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …

Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …

Many transcription factors (TFs) localize in nuclear clusters of locally increased
concentrations, but how TF clustering is regulated and how it influences gene expression is …

The binding of transcription factors (TFs) along genomes is restricted to a subset of sites
containing their preferred motifs. TF-binding specificity is often attributed to the co-binding of …

Transcription factors activate gene expression in development, homeostasis, and stress with
DNA binding domains and activation domains. Although there exist excellent computational …

Transcription factors (TFs) are classically attributed a modular construction, containing well-
structured sequence-specific DNA-binding domains (DBDs) paired with disordered …

Chromatin is a barrier to the binding of many transcription factors. By contrast, pioneer
factors access nucleosomal targets and promote chromatin opening. Despite binding to …

Whether phase-separation is involved in the organization of the transcriptional machinery
and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini …