Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes
including cell proliferation, differentiation and DNA repair. Changes in these pathways can …

Advances in understanding how cancer cells interact with the immune system allowed the
development of immunotherapeutic strategies, harnessing patients' immune system to fight …

Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its
effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide …

Purpose: We explored the prognostic effect of PIK3CA mutation in HER2+ patients enrolled
in the ShortHER trial. Patients and Methods: The ShortHER trial randomized 1,253 patients …

Large-scale genome-wide associations comprising multiple studies have identified
hundreds of genetic loci commonly associated with hyperlipidemia-related phenotypes …

Few germline genetic variants have been robustly linked with breast cancer outcomes. We
conducted trans-ethnic meta genome-wide association study (GWAS) of overall survival …

Immune-related genes (IRGs) play regulatory roles in the immune system and are involved
in the initiation and progression of colon cancer. This study aimed to develop an …

Background: Glomerular endothelial cell damage plays an important role in the occurrence
and development of diabetic nephropathy (DN). Objectives: This study aimed to clarify the …

Background: Despite the potential role of several chemokines in the migration of cytotoxic
immune cells to prohibit breast cancer cell proliferation, a comprehensive view of …