Landmarks in vaginal mesh development: polypropylene mesh for treatment of SUI and POP

N Mangir, B Aldemir Dikici, CR Chapple… - Nature Reviews …, 2019 - nature.com
Vaginal meshes used in the treatment of stress urinary incontinence (SUI) and pelvic organ
prolapse (POP) have produced highly variable outcomes, causing life-changing …

Methods for implant acceptance and wound healing: material selection and implant location modulate macrophage and fibroblast phenotypes

A Boddupalli, L Zhu, KM Bratlie - Advanced Healthcare …, 2016 - Wiley Online Library
This review focuses on materials and methods used to induce phenotypic changes in
macrophages and fibroblasts. Herein, we give a brief overview on how changes in …

[HTML][HTML] Assessment of electrospun and ultra-lightweight polypropylene meshes in the sheep model for vaginal surgery

L Hympanova, R Rynkevic, S Roman… - European urology …, 2020 - Elsevier
Background There is an urgent need to develop better materials to provide anatomical
support to the pelvic floor without compromising its function. Objective Our aim was to …

[HTML][HTML] Application of synthetic and natural polymers in surgical mesh for pelvic floor reconstruction

M Yuan, M Hu, F Dai, Y Fan, Z Deng, H Deng… - Materials & Design, 2021 - Elsevier
Pelvic floor dysfunction (PFD) is a common gynecological problem that affects millions of
women. Current treatment strategies are to restore the normal anatomical structure by non …

Oestradiol-releasing biodegradable mesh stimulates collagen production and angiogenesis: an approach to improving biomaterial integration in pelvic floor repair

N Mangır, CJ Hillary, CR Chapple, S MacNeil - European urology focus, 2019 - Elsevier
Background Polypropylene meshes cause severe complications in some patients. Materials
that are biomechanically compatible and can better integrate into host tissues are urgently …

Urogynecological surgical mesh implants: New trends in materials, manufacturing and therapeutic approaches

ZL Farmer, J Domínguez-Robles, C Mancinelli… - International Journal of …, 2020 - Elsevier
Abstract Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI) are two
prevalent disorders affecting 30–40% of women worldwide. Current strategies to repair or …

Demonstration of improved tissue integration and angiogenesis with an elastic, estradiol releasing polyurethane material designed for use in pelvic floor repair

S Shafaat, N Mangir, SR Regureos… - Neurourology and …, 2018 - Wiley Online Library
Aims Pelvic organ prolapse and stress urinary incontinence affect 40‐50% of
postmenopausal women worldwide. Polypropylene meshes have been extensively used for …

Evaluation of the short‐term host response and biomechanics of an absorbable poly‐4‐hydroxybutyrate scaffold in a sheep model following vaginal implantation

CM Diedrich, Z Guler, L Hympanova… - … Journal of Obstetrics …, 2022 - Wiley Online Library
Objective To evaluate the host‐and biomechanical response to a fully absorbable poly‐4‐
hydroxybutyrate (P4HB) scaffold in comparison with the response to polypropylene (PP) …

The use of polymeric meshes for pelvic organ prolapse: Current concepts, challenges, and future perspectives

E Mancuso, C Downey, E Doxford‐Hook… - … Research Part B …, 2020 - Wiley Online Library
Pelvic organ prolapse (POP) is one of the most common chronic disorders in women,
impacting the quality of life of millions of them worldwide. More than 100 surgical procedures …

3D printable hydrogel with tunable degradability and mechanical properties as a tissue scaffold for pelvic organ prolapse treatment

Y Zhu, T Kwok, JC Haug, S Guo, X Chen… - Advanced Materials …, 2023 - Wiley Online Library
Pelvic organ prolapse (POP) is a dysfunction that affects a large proportion of women.
Current support scaffolds' lack of biocompatibility, biodegradability, and mechanical …