Controlled proteolysis underlies a vast diversity of protective and regulatory processes that
are of key importance to cell fate. The unique molecular architecture of the widely conserved …

Short sequence motifs are ubiquitous across the three major types of biomolecules:
hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs …

Recycling of internalized receptors from endosomal compartments is essential for the
receptors' cell-surface homeostasis. Sorting nexin 27 (SNX27) cooperates with the retromer …

Biochemical activity and core stability are essential properties of proteins, maintained
usually by conserved amino acids. Structural dynamics emerged in recent years as another …

Globular PDZ domains typically serve as protein–protein interaction modules that regulate a
wide variety of cellular functions via recognition of short linear motifs (SLiMs). Often, PDZ …

Here, we systematically decompose the known protein structural universe into its basic
elements, which we dub tertiary structural motifs (TERMs). A TERM is a compact backbone …

Voltage-gated calcium (Cav) channels serve dual roles in the cell, where they can both
depolarize the membrane potential for electrical excitability, and activate transient …

Abstract The site-1 and site-2 proteases (S1P and S2P) were identified over 20 years ago,
and the functions of both have been addressed in numerous studies ever since. Whereas …

The evolutionary origin of synapses and neurons is an enigmatic subject that inspires much
debate. Non‐bilaterian metazoans, both with and without neurons and their closest relatives …

Assembly of a functioning neuronal synapse requires the precisely coordinated synthesis of
many proteins. To understand the evolution of this complex cellular machine, we tracked the …