Background Hirschsprung's disease (HSCR) is a serious congenital bowel disorder with a
prevalence of 1/5000. Currently, there is a lack of systematically developed guidelines to …

Diagnosis or exclusion of Hirschsprung disease (HSCR) is a frequent exercise in any
pediatric hospital. Although HSCR may present at different ages and with varied clinical …

Objective: Primary gastrointestinal neuropathies are a heterogeneous group of enteric
nervous system (ENS) disorders that continue to cause difficulties in diagnosis and …

Alzheimer's disease (AD) exhibits distinct biochemical and histopathological attributes,
encompassing cellular, neuronal, and oxidative impairment. There is also an abnormal …

Hirschsprung disease (HSCR) is a multigenic condition with variable presentation. Most
commonly, it presents in the neonatal period as a functional intestinal obstruction secondary …

Background This study aimed to identify key microRNAs (miRNAs), pathways, and target
genes mediating Hirschsprung's disease (HSCR) pathogenesis and identify the diagnostic …

Context.—Up to 17% of all rectal suction biopsies performed in the evaluation of
Hirschsprung disease are considered inadequate. In most instances, inadequate biopsies …

Objectives: The detection of ganglion cells in rectal biopsies of infants or toddlers with
severe constipation is routinely performed by pediatric pathologists in many institutions …

Historically, the diagnosis of Hirschsprung disease was made by evaluating multiple
hematoxylin and eosin–stained slides and performing acetylcholinesterase histochemical …

Absent calretinin-immunoreactive (CRir) mucosal innervation in aganglionic rectal biopsies
is considered a useful diagnostic finding for Hirschsprung disease. Analysis of a series of …