Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics

A Shankar, KK Sharma - Applied Microbiology and Biotechnology, 2022 - Springer
Fungi produce several bioactive metabolites, pigments, dyes, antioxidants, polysaccharides,
and industrial enzymes. Fungal products are also the primary sources of functional food and …

Genetic crosses within and between species of Cryptosporidium

S Shaw, IS Cohn, RP Baptista, G Xia… - Proceedings of the …, 2024 - National Acad Sciences
Parasites and their hosts are engaged in reciprocal coevolution that balances competing
mechanisms of virulence, resistance, and evasion. This often leads to host specificity, but …

Life Cycle and Transmission of Cyclospora cayetanensis: Knowns and Unknowns

JP Dubey, A Khan, BM Rosenthal - Microorganisms, 2022 - mdpi.com
Although infections with Cyclospora cayetanensis are prevalent worldwide, many aspects of
this parasite's life cycle and transmission remain unknown. Humans are the only known …

Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

JC Hanna, V Corpas-Lopez, S Seizova… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Cryptosporidiosis is a leading cause of diarrheal-associated morbidity and
mortality, predominantly affecting children under 5 years old in low-and-middle-income …

Transcriptional control of the Cryptosporidium life cycle

KA Walzer, J Tandel, JH Byerly, AM Daniels… - Nature, 2024 - nature.com
The parasite Cryptosporidium is a leading agent of diarrhoeal disease in young children,
and a cause and consequence of chronic malnutrition,. There are no vaccines and only …

Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis

CA Gilchrist, JJ Campo, JV Pablo… - The Journal of …, 2023 - Am Soc Clin Investig
There is no vaccine to protect from cryptosporidiosis, a leading cause of diarrhea in infants
in low-and middle-income countries. Here, we comprehensively identified parasite antigens …

Recent genetic exchanges and admixture shape the genome and population structure of the zoonotic pathogen Cryptosporidium parvum

GI Corsi, S Tichkule, AR Sannella, P Vatta… - Molecular …, 2023 - Wiley Online Library
Cryptosporidium parvum is a globally distributed zoonotic pathogen and a major cause of
diarrhoeal disease in humans and ruminants. The parasite's life cycle comprises an …

The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell

JE Dumaine, A Sateriale, AR Gibson, AG Reddy… - Elife, 2021 - elifesciences.org
The parasite Cryptosporidium is responsible for diarrheal disease in young children causing
death, malnutrition, and growth delay. Cryptosporidium invades enterocytes where it …

Sequence introgression from exogenous lineages underlies genomic and biological differences among Cryptosporidium parvum IOWA lines

W Huang, K Tang, C Chen, MJ Arrowood, M Chen… - Water research, 2024 - Elsevier
The IOWA strain of Cryptosporidium parvum is widely used in studies of the biology and
detection of the waterborne pathogens Cryptosporidium spp. While several lines of the strain …

Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes

W Huang, W He, Y Huang, Y Tang, M Chen… - Nature …, 2024 - nature.com
The anthroponotic Cryptosporidium hominis differs from the zoonotic C. parvum in its lack of
infectivity to animals, but several divergent subtypes have recently been found in nonhuman …