Heparan sulfate proteoglycan in Alzheimer's disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism
I Ozsan McMillan, JP Li, L Wang - American Journal of …, 2023 - journals.physiology.org
Alzheimer's disease (AD) is the most common form of dementia. Currently, there is no
effective treatment for AD, as its etiology remains poorly understood. Mounting evidence …
effective treatment for AD, as its etiology remains poorly understood. Mounting evidence …
Emerging concepts towards a translational framework in Alzheimer's disease
Over the past decades, significant efforts have been made to understand the precise
mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common …
mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common …
Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions
MT Odenkirk, X Zheng, JE Kyle… - Journal of Proteome …, 2024 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease with a complex etiology
influenced by confounding factors such as genetic polymorphisms, age, sex, and race …
influenced by confounding factors such as genetic polymorphisms, age, sex, and race …
Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis …
E Thanou, F Koopmans, D Pita-Illobre, RV Klaassen… - Cells, 2023 - mdpi.com
Suspension TRAPping filter (sTRAP) is an attractive sample preparation method for
proteomics studies. The sTRAP protocol uses 5% SDS that maximizes protein solubilization …
proteomics studies. The sTRAP protocol uses 5% SDS that maximizes protein solubilization …
Identifying sex-specific serum patterns of Alzheimer's mice through deep TMT profiling and a concentration-dependent concatenation strategy
Alzheimer's disease (AD) is the most prevalent form of dementia, disproportionately affecting
women in disease prevalence and progression. Comprehensive analysis of the serum …
women in disease prevalence and progression. Comprehensive analysis of the serum …
Protocol for biospecimen collection and analysis within the BACPAC research program
Abstract The Biospecimen Collection and Processing Working Group of the National
Institutes of Health (NIH) HEAL Initiative BACPAC Research Program was charged with …
Institutes of Health (NIH) HEAL Initiative BACPAC Research Program was charged with …
Methionine Sulfoxide Speciation in Mouse Hippocampus Revealed by Global Proteomics Exhibits Age-and Alzheimer's Disease-Dependent Changes Targeted to …
Methionine oxidation to the sulfoxide form (MS ox) is a poorly understood post-translational
modification of proteins associated with non-specific chemical oxidation from reactive …
modification of proteins associated with non-specific chemical oxidation from reactive …
Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer's Disease Pathogenesis
DR Tabuena, SS Jang, B Grone, O Yip, EA Aery Jones… - bioRxiv, 2023 - biorxiv.org
The impact of apolipoprotein E4 (apoE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on neuronal function remains unclear. We investigated this by examining …
disease (AD), on neuronal function remains unclear. We investigated this by examining …
[HTML][HTML] Exploring temporal and sex-linked dysregulation in Alzheimer disease phosphoproteome
This study aims to characterize dysregulation of phosphorylation for the 5XFAD mouse
model of Alzheimer disease (AD). Employing global phosphoproteome measurements, we …
model of Alzheimer disease (AD). Employing global phosphoproteome measurements, we …
[PDF][PDF] Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer's Disease Pathogenesis
The full impact of apolipoprotein E4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on neuronal and network function remains unclear. We found hippocampal …
disease (AD), on neuronal and network function remains unclear. We found hippocampal …