Controlling drug release with additive manufacturing-based solutions
Abstract 3D printing is an innovative manufacturing technology with great potential to
revolutionise solid dosage forms. Novel features of 3D printing technology confer advantage …
revolutionise solid dosage forms. Novel features of 3D printing technology confer advantage …
Applications of QSAR study in drug design of tubulin binding inhibitors
SK Sahu, KK Ojha - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
New drug discovery is recognized as a complicated, costly, time-consuming, and difficult
process. Computer-aided drug discovery has developed as a potent and promising method …
process. Computer-aided drug discovery has developed as a potent and promising method …
Identification of potential agonist-like molecules for α2-adrenergic receptor by multi-layer virtual screening to combat sinusitis
Sinusitis is one of the most common respiratory inflammatory conditions and a significant
health issue that affects millions of people worldwide with a global prevalence of 10–15 …
health issue that affects millions of people worldwide with a global prevalence of 10–15 …
Structural insights on vitamin D receptor and screening of new potent agonist molecules: structure and ligand-based approach
JM Jayaraj, E Reteti, C Kesavan… - Journal of Biomolecular …, 2021 - Taylor & Francis
Vitamin D deficiency is one of the common clinical symptoms of severe chronic kidney
disease (CKD) patients. Vitamin D receptor (VDR) is a part of the nuclear receptor family …
disease (CKD) patients. Vitamin D receptor (VDR) is a part of the nuclear receptor family …
Therapeutic Potential of a Novel Vitamin D3 Oxime Analogue, VD1-6, with CYP24A1 Enzyme Inhibitory Activity and Negligible Vitamin D Receptor Binding
AK Alshabrawy, Y Cui, C Sylvester, D Yang, ES Petito… - Biomolecules, 2022 - mdpi.com
The regulation of vitamin D3 actions in humans occurs mainly through the Cytochrome P450
24-hydroxylase (CYP24A1) enzyme activity. CYP24A1 hydroxylates both 25 …
24-hydroxylase (CYP24A1) enzyme activity. CYP24A1 hydroxylates both 25 …
Exploring the rare variants associated with Type 2 Diabetes Mellitus in Indian population and its disease-drug association studies: an in-silico approach
G Shelake, S Baviskar, AK Panda… - Journal of …, 2024 - Taylor & Francis
The diversified eating habits and religious culture of Indian population may be one of the
reasons they largely contribute to the global diabetes burden. In the present investigation …
reasons they largely contribute to the global diabetes burden. In the present investigation …
Theoretical investigation on known renin inhibitors and generation of ligand-based pharmacophore models for hypertension treatment
L Loganathan, J Sankar, K Rajendran… - Journal of …, 2023 - Taylor & Francis
The renin enzyme is considered a promising target for hypertension and renal diseases.
Over the last three decades, several experimental and theoretical studies have been …
Over the last three decades, several experimental and theoretical studies have been …
CYP24A1: structure, function, and physiological role
R St-Arnaud, G Jones - Vitamin D, 2018 - Elsevier
CYP24A1 is a mitochondrial inner-membrane cytochrome P450 enzyme that exhibits
multifunctionality: it is able to hydroxylate both the C23 or the C24 side-chain carbons of 25 …
multifunctionality: it is able to hydroxylate both the C23 or the C24 side-chain carbons of 25 …
Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson's disease
J John Marshal, BB Kuriakose… - Journal of Cellular …, 2023 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disorder that
affects dopaminergic neurons in the midbrain. A recent study suggests that Orphan Nuclear …
affects dopaminergic neurons in the midbrain. A recent study suggests that Orphan Nuclear …
Role of deleterious nsSNPs of klotho protein and their drug response: A computational mechanical insights
JM Jayaraj, K Muthusamy - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Worldwide, the burden of chronic kidney disease (CKD) has increased rapidly and is a lethal
disease. The klotho protein plays a vital role in the regulatory mechanism in the progression …
disease. The klotho protein plays a vital role in the regulatory mechanism in the progression …