Aryl hydrocarbon receptor (AhR) is a member of the basic helix–loop–helix–(bHLH)
superfamily of transcription factors, which are associated with cellular responses to …

Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important
effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn …

Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are
associated with dysbiosis of the gut microbiome. Emerging evidence suggests that small …

While modulatory effects of gut microbes on neurological phenotypes have been reported,
the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan …

The epithelium and immune compartment in the intestine are constantly exposed to a
fluctuating external environment. Defective communication between these compartments at …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

The gut microbiota play a pivotal role in human health. Emerging evidence indicates that gut
microbes participate in the progression of tumorigenesis through the generation of …

Pressure-overloaded left ventricular remodeling in young population is progressive and
readily degenerate into heart failure. The aims of this study were to identify a plasma …

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …