Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …

Cellular metabolites are ancient molecules with pleiotropic implications in health and
disease. Beyond their cognate roles, they have signaling functions as the ligands for specific …

Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for
cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 …

Serine is a vital amino acid in tumorigenesis. While cells can perform de novo serine
synthesis, most transformed cells rely on serine uptake to meet their increased biosynthetic …

The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse
biosynthetic functions. While some tumors can synthesize serine de novo, others are …

Blocking the import of nutrients essential for cancer cell proliferation represents a
therapeutic opportunity, but it is unclear which transporters to target. Here we report a …

Metabolic changes contribute to cancer initiation and progression through effects on cancer
cells, the tumor microenvironment and whole-body metabolism. Alterations in serine …

Breast cancer (BC) is a malignant tumor that seriously endangers health in women. BC, like
other cancers, is accompanied by metabolic reprogramming. Among energy metabolism …

Serine is a metabolite with ever-expanding metabolic and non-metabolic signaling
attributes. By providing one‑carbon units for macromolecule biosynthesis and functional …

Metabolic reprogramming is one of the hallmarks of tumor. Growing evidence suggests
metabolic changes that support oncogenic progression may cause selective vulnerabilities …