Current challenges and opportunities of photodynamic therapy against cancer

RV Huis in 't Veld, J Heuts, S Ma, LJ Cruz… - Pharmaceutics, 2023 - mdpi.com
BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive
treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are …

Recent advances in functional nanomaterials for light–triggered cancer therapy

S Gai, G Yang, P Yang, F He, J Lin, D Jin, B Xing - Nano today, 2018 - Elsevier
Photo–triggered therapeutic modalities for cancer have attracted enormous attention in
recent years due to the easily focused and tuned properties of irradiation light that enable …

EGFR-targeted photodynamic therapy

L Ulfo, PE Costantini, M Di Giosia, A Danielli… - Pharmaceutics, 2022 - mdpi.com
The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and
metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are …

Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization—a Thomas Dougherty Award for Excellence in …

P De Silva, MA Saad, HC Thomsen, S Bano… - Journal of Porphyrins …, 2020 - World Scientific
Photodynamic therapy is a photochemistry-based approach, approved for the treatment of
several malignant and non-malignant pathologies. It relies on the use of a non-toxic, light …

[HTML][HTML] Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment …

MM Deken, MM Kijanka, IB Hernández… - Journal of controlled …, 2020 - Elsevier
Rationale A substantial number of breast cancer patients with an overexpression of the
human epidermal growth factor receptor 2 (HER2) have residual disease after neoadjuvant …

Photodynamic therapy in head and neck cancer: indications, outcomes, and future prospects

J Meulemans, P Delaere… - Current opinion in …, 2019 - journals.lww.com
The value of PDT in specific well-selected head and neck cancer clinical scenarios is well
established. The basic research field is rapidly evolving and experimental findings are …

Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy

SRG Fernandes, R Fernandes, B Sarmento… - Organic & …, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) combines a photosensitizer (PS) with the physical energy of
non-ionizing light to trigger cell death pathways. PDT has potential as a therapeutic modality …

Immune checkpoint inhibition combined with targeted therapy using a novel virus-like drug conjugate induces complete responses in a murine model of local and …

RV Huis in 't Veld, S Ma, RC Kines… - Cancer Immunology …, 2023 - Springer
Metastases remain the leading cause of cancer-related death worldwide. Therefore,
improving the treatment efficacy against such tumors is essential to enhance patient survival …

[HTML][HTML] Near-infrared photoimmunotherapy: design and potential applications for cancer treatment and beyond

D Wei, J Qi, MR Hamblin, X Wen, X Jiang, H Yang - Theranostics, 2022 - ncbi.nlm.nih.gov
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment
modality based on a target-specific photosensitizer conjugate (TSPC) composed of an NIR …

Recent advances in hydrogels for preventing tumor recurrence

Q Qian, J Song, C Chen, Q Pu, X Liu, H Wang - Biomaterials Science, 2023 - pubs.rsc.org
Malignant tumors remain a high-risk disease with high mortality all over the world. Among all
the cancer treatments, surgery is the primary approach in the clinical treatment of tumors …