Determining the role of microRNAs in psychiatric disorders
Recent studies have revealed that patients with psychiatric disorders have altered
microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal …
microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal …
Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability
J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
MiR-137: an important player in neural development and neoplastic transformation
E Mahmoudi, MJ Cairns - Molecular psychiatry, 2017 - nature.com
MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …
DNA methylation and schizophrenia: current literature and future perspective
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …
identity, and emotions. It has no central pathophysiological mechanism and precise …
Dysregulation of miRNA-9 in a subset of schizophrenia patient-derived neural progenitor cells
Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for
schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control …
schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control …
MicroRNA-137 controls AMPA-receptor-mediated transmission and mGluR-dependent LTD
Mutations affecting the levels of microRNA miR-137 are associated with intellectual disability
and schizophrenia. However, the pathophysiological role of miR-137 remains poorly …
and schizophrenia. However, the pathophysiological role of miR-137 remains poorly …
A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder
Schizophrenia (SZ) genome-wide association studies (GWASs) have identified common risk
variants in> 100 susceptibility loci; however, the contribution of rare variants at these loci …
variants in> 100 susceptibility loci; however, the contribution of rare variants at these loci …
Genetics of schizophrenia: historical insights and prevailing evidence
Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …
several decades; however, despite the clear evidence for a genetic component, it has been …
An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function
M Kambali, Y Li, P Unichenko, JA Feria Pliego… - Molecular …, 2024 - nature.com
Glycine is an obligatory co-agonist at excitatory NMDA receptors in the brain, especially in
the dentate gyrus, which has been postulated to be crucial for the development of psychotic …
the dentate gyrus, which has been postulated to be crucial for the development of psychotic …
MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission
E He, MAG Lozano, S Stringer… - Human molecular …, 2018 - academic.oup.com
The MIR137 locus is a replicated genetic risk factor for schizophrenia. The risk-associated
allele is reported to increase miR-137 expression and miR-137 overexpression alters …
allele is reported to increase miR-137 expression and miR-137 overexpression alters …