Linking human milk oligosaccharide metabolism and early life gut microbiota: Bifidobacteria and beyond

C Lordan, AK Roche, D Delsing, A Nauta… - Microbiology and …, 2024 - Am Soc Microbiol
Human milk oligosaccharides (HMOs) are complex, multi-functional glycans present in
human breast milk. They represent an intricate mix of heterogeneous structures which reach …

Early-life exposures and the microbiome: implications for IBD prevention

L Zhang, M Agrawal, SC Ng, T Jess - Gut, 2024 - gut.bmj.com
The early-life period is one of microbiome establishment and immune maturation. Early-life
exposures are increasingly being recognised to play an important role in IBD risk. The …

Primary succession of Bifidobacteria drives pathogen resistance in neonatal microbiota assembly

Y Shao, C Garcia-Mauriño, S Clare, NJR Dawson… - Nature …, 2024 - nature.com
Human microbiota assembly commences at birth, seeded by both maternal and
environmental microorganisms. Ecological theory postulates that primary colonizers dictate …

Maternal breastfeeding is associated with offspring microbiome diversity; a secondary analysis of the MicrobeMom randomized control trial

CA Yelverton, SL Killeen, C Feehily, RL Moore… - Frontiers in …, 2023 - frontiersin.org
Background Microbial dysbiosis in infancy can influence long-term health outcomes such as
childhood obesity. The aim of this study is to explore relationships among maternal well …

Seeding the Infant Gut in Early Life—Effects of Maternal and Infant Seeding with Probiotics on Strain Transfer, Microbiota, and Gastrointestinal Symptoms in Healthy …

C Melsaether, D Høtoft, A Wellejus, GDA Hermes… - Nutrients, 2023 - mdpi.com
We investigated the effects of two dosing regimens of two multi-strain probiotic products on
the gut microbiota of breastfed infants, including the transfer of the dosed strains and clinical …

Selective human milk oligosaccharide utilization by members of the Bifidobacterium pseudocatenulatum taxon

R Sanchez-Gallardo, F Bottacini, IJ O'Neill… - Applied and …, 2024 - journals.asm.org
Human milk oligosaccharides (HMOs) are essentially unaffected by the digestive enzymes
of the nursling and are known for their ability to enrich certain microbial species in the infant …

Unveiling metabolic pathways of selected plant-derived glycans by Bifidobacterium pseudocatenulatum

R Sanchez-Gallardo, F Bottacini, L Friess… - Frontiers in …, 2024 - frontiersin.org
Bifidobacteria are commonly encountered members of the human gut microbiota that
possess the enzymatic machinery necessary for the metabolism of certain plant-derived …

[HTML][HTML] Bacteriophage communities are a reservoir of unexplored microbial diversity in neonatal health and disease

GR Young, A Nelson, CJ Stewart, DL Smith - Current Opinion in …, 2023 - Elsevier
Acquisition and development of the gut microbiome are vital for immune education in
neonates, especially those born preterm. As such, microbial communities have been …

An optimized culturomics strategy for isolation of human milk microbiota

F Wang, L Yu, Y Ren, Q Zhang, S He, M Zhao… - Frontiers in …, 2024 - frontiersin.org
Viable microorganisms and a diverse microbial ecosystem found in human milk play a
crucial role in promoting healthy immune system and shaping the microbial community in …

Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

TC Barker-Tejeda, E Zubeldia-Varela… - Nature …, 2024 - nature.com
The human gut microbiome establishes and matures during infancy, and dysregulation at
this stage may lead to pathologies later in life. We conducted a multi-omics study comprising …